Featured Publications
Below are some recent publications highlighting the broad scientific impact of the Oak Crest Institute of Science. For a complete list and impact metrics, visit our institution page on Research Gate.
2023
Gallay et al.Acute Antagonism in Three-drug Combinations for Vaginal HIV Prevention in Humanized Mice. Sci. Rep. 2023, 13 (1), 4594.
Download: https://www.nature.com/articles/s41598-023-31695-5
2022
Gunawardana et al. Early SARS-CoV-2 Dynamics and Immune Responses in Unvaccinated Participants of an Intensely Sampled Longitudinal Surveillance Study. Commun. Med. 2022, 2, 129.
Download: https://www.nature.com/articles/s43856-022-00195-4.pdf
Press Release: https://www.prnewswire.com/news-releases/covid-study-of-unvaccinated-sample-puts-cutting-edge-research-on-the-map-301661067.html
Gunawardana et al. Clinical SARS-CoV-2 Kinetic Profiles Are Dependent on the Viral Strain and Host Vaccination Status. Microbiol Spectr. 2022 Dec 21;10(6):e0446922. doi: 10.1128/spectrum.04469-22. Epub 2022 Dec 1.
Download: https://journals.asm.org/doi/full/10.1128/spectrum.04469-22
Press Release: https://pharmaceuticalnewswire.com/press-release/sars-cov-2-virus-kinetics-influenced-by-viral-strain-and-vaccination-status-301696245/
Gunawardana et al. Fundamental Aspects of Long-acting Tenofovir Alafenamide Delivery from Subdermal Implants for HIV Prophylaxis. Sci. Rep. 2022, 12 (1), 8224.
Download: https://link.springer.com/content/pdf/10.1038/s41598-022-11020-2.pdf
Barge et al. Prebiotic Reactions in a Mars Analog Iron Mineral System: Effects of Nitrate, Nitrite, and Ammonia on Amino Acid Formation. Geochim. Cosmochim. Acta 2022, 336, 469-479.
Download: https://web.gps.caltech.edu/~yly/yly_mac/ReprintsYLY/N429_barge_2022_mars_iron.pdf
Han et al. Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila. Elife. 2022 Aug 22;11:e77924. doi: 10.7554/eLife.77924. Epub ahead of print. PMID: 35993544.
Download: https://elifesciences.org/articles/77924.pdf
Danese et al. Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy. Cell Rep. 2022 Jul 19;40(3):111124. doi: 10.1016/j.celrep.2022.111124. PMID: 35858578; PMCID: PMC9314546.
Download: https://doi.org/10.1016/j.celrep.2022.111124
Gengiah et al. CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women. BMJ Open. 2022 Jan 6;12(1):e052880. doi: 10.1136/bmjopen-2021-052880. PMID: 34992111; PMCID: PMC8739430.
Download: https://doi.org/10.1136/bmjopen-2021-052880
2021
Gunawardana et al. 2021. Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints. mSphere 2021, 6 (4), e0054221.
Download: https://journals.asm.org/doi/full/10.1128/mSphere.00542-21
Romano et al. 2021. Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting. AIDS Res Hum Retroviruses. 2021 Jun;37(6):409-420. doi: 10.1089/AID.2021.0028. PMID: 33913760; PMCID: PMC8213003.
Download: https://doi.org/10.1089/aid.2021.0028
Bobardt et al. 2021. The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance. PLOS ONE 16(5): e0251934.
Download: https://doi.org/10.1371/journal.pone.0251934
Bao et al. 2021. Human RGR Gene and Associated Features of Age-related Macular Degeneration Revealed in Models of Retina-Choriocapillaris Atrophy. Am J Pathol. 2021 May 19:S0002-9440(21)00202-9.
Download: doi: 10.1016/j.ajpath.2021.05.003.
2020
Baum et al. 2020. Highly Synergistic Drug Combination Prevents Vaginal HIV Infection in Humanized Mice. Sci. Rep. 2020, 10 (1), 12995.
Download: https://www.nature.com/articles/s41598-020-69937-5
Aguirre et al. 2020. Synthesis and Characterization of Mixed-Valent Iron Layered Double Hydroxides (“Green Rust”). ACS Earth Space Chem. 2020, Epub ahead of print Dec. 19.
Download: https://doi.org/10.1021/acsearthspacechem.0c00272
Hooks et al 2020. Effects of amino acids on iron-silicate chemical garden precipitation. 2020. Langmuir. doi.org/10.1021/acs.langmuir.0c00502
Download: https://pubs.acs.org/doi/10.1021/acs.langmuir.0c00502
Webster et al 2020. Concentrative nucleotide transporter 3 is located in microvilli on vaginal epithelial cells. ACS Omega 2020.
Download: https://dx.doi.org/10.1021/acsomega.0c02329
Webster et al 2020. Equilibrative nucleoside transporter 1 (SLC29A1) localization on vaginal epithelial cells. J. Histology & Histopathology. ISSN 2055-091X, Volume 7, Article 5. 2020
2019
Barge et al. 2019. Redox and pH Gradients Drive Amino Acid Synthesis in Iron Oxyhydroxide Mineral Systems. Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (11), 4828-4833.
Download: https://www.pnas.org/doi/full/10.1073/pnas.1812098116
2018
Vincent et al. 2018. Safety and Pharmacokinetics of Single, Dual, and Triple Antiretroviral Drug Formulations Delivered by Pod-intravaginal Rings Designed for HIV-1 Prevention: A Phase I Trial. PLos Med. 2018, 15 (9).
Download: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002655
2017
Bock et al. 2017. Dicarboxylic Acid Emissions from Aftertreatment Equipped Diesel Engines. Environ. Sci. Technol. 2017, 51 (21), 13036-13043.
Download: https://doi.org/10.1021/acs.est.7b03868
Smith et al. 2017. Novel Multipurpose Pod-intravaginal Ring for the Prevention of HIV, HSV, and Unintended Pregnancy: Pharmacokinetic Evaluation in a Macaque Model. PLoS One 2017, 12 (10), e0185946.
Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185946
2016
Srinivasan et al. 2016. Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures. PLoS One 2016, 11 (6), e0157061.
Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157061
2015
Gunawardana et al. 2015. Euphorbia Plant Latex Is Inhabited by Diverse Microbial Communities. Am. J. Bot. 2015, 102 (12), 1966-1977. doi:10.3732/ajb.1500223
Download: https://bsapubs.onlinelibrary.wiley.com/doi/pdf/10.3732/ajb.1500223
Baum et al. 2015. An Intravaginal Ring for the Sustained Delivery of Tenofovir Disoproxil Fumarate. Int. J. Pharm. 2015, 495 (1), 579-587. doi: 10.1016/j.ijpharm.2015.09.028
Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609628/
2014
Gunawardana et al. 2014. Isolation of PCR Quality Microbial Community DNA from Heavily Contaminated Environments. J. Microbiol. Methods 2014, 102, 1-7.
Gunawardana et al. 2014.An Intravaginal Ring for the Sustained Delivery of Antibodies. J. Pharm. Sci. 2014, 103 (11), 3611-3620. doi: 10.1002/jps.24154
Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206599/
Wu et al 2014. Biofilm-specific extracellular matrix proteins of non-typeable Haemophilus influenzae. Pathog Dis. 2014 Jun 19. doi: 10.1111/2049-632X.12195. PMID: 24942343.